Yokohama City University

Effect of early healthcare visits on cardiovascular disease risk in people with newly screened diabetes: emulating a target trial using a large insurance database

2025.12.15

Highlights


● Target trial emulation on 148,288 Japanese adults with newly screened diabetes and no prior CVD.

● Early visits within 1 year of screening were associated with a 27% lower 10-year CVD risk.

● 10-year absolute risk difference was −3.4 % (risk ratio 0.73) for early vs no visits.

● The association was consistent across age, sex, baseline glycemia, and medication subgroups.

● Findings support policies facilitating prompt follow-up after diabetes screening. 

Abstract

Aims

To determine whether healthcare visits within one year after diabetes identification lower 10-year cardiovascular disease (CVD) risk compared with no visits. 

Methods

 We emulated a target trial in the nationwide JMDC Claims Database (>12 million Japanese beneficiaries). Adults aged 40–74 years with newly identified diabetes (HbA1c ≥ 6.5 % [48 mmol/mol] or fasting glucose ≥126 mg/dL) during annual health checkups between 1 January 2005 and 31 March 2021 and no prior history of CVD were assigned to an early-visit group (≥1 outpatient visit within one year) or a no-visit group. Weighted pooled logistic regression estimated 10-year risk differences and risk ratios for a composite CVD outcome.

Results

Among 148,288 participants (mean age 53 years; 77 % men; 421,466 person-years), 1,741 CVD events occurred. Early visits were associated with a lower 10-year composite CVD risk compared to no visits (risk difference –3.4 percentage points [95 % CI –6.2 to –1.4]; risk ratio 0.73 [95 % CI 0.59 to 0.87]). Subgroup analyses confirmed consistent results across various characteristics. 

Conclusions

Early healthcare visits within one year of diabetes identification were associated with a lower 10-year CVD risk. Health systems should facilitate early follow-up after screening to translate early detection into cardiovascular benefit. 

For inquiries regarding this article

Atsushi Goto
Professor
Department of Health Data Science, Yokohama City University Graduate School of Data Science
Department of Public Health, School of Medicine, Yokohama City University
Yokohama, Japan