In order to convert the results of basic research on advanced medical therapies and drugs into useful technologies in clinical settings for disease prevention, diagnosis and treatment. Translational research moves away from the conventional system in which individual research laboratories engage in their own research, instead building platforms that enable labs to consolidate knowledge and cooperate cross-functionally on new Research & Development efforts.
To accomplish this, AMRC has seven research laboratories. As a result, it can develop cutting-edge joint research activities at every level, from genomics to proteomics, to cellomics, and collect and use specimens of excellent quality and content from human subjects as medical resources.
To further develop these research seeds and use them to benefit society at large, we have created laboratories for companies and promoted industry-academia collaboration. We are also working to bolster the functions of those laboratories so that they and their equipment can be used interactively and effectively.
Director, Department of Research Support and Coordination
Professor, Department of Physiology, Graduate School of Medicine
Genome Research Center
Center for genetic and genomic researches. The modern next generation sequencers are equipped to develop innovative diagnostic and predictive methods based on human genome data for rare hereditary and intractable diseases and personalized medicine.
- Next-Generation Sequencing System
- DNA Microarray Scanner
- Capillary Sequencer
- Real-Time PCR System
Proteome Research Center
Eight of the latest mass spectrometers are equipped for protein or proteome analyses in this laboratory. Here we are able to detect and identify diagnostic markers, proteins that can act as potential drug targets, disease-causing proteins, etc., and verify the usefulness of these diagnostic markers and drug development target molecules.
- Mass spectrometer
- High performance liquid chromatography
- Laser microdissection
Cellome Research Center
This center conducts analyses at the cellular level. Fully furnished with cell sorters and other modern equipment for cutting-edge cell biology, our center carries out research on the basis of human stem cell separation/manipulation and genetic engineering technologies. We aim to develop innovative therapies for organ failure, cancer, life-style diseases and infectious diseases, such as regenerative medicine and the development of new anti-cancer drugs.
- Cell Sorter (Jet-in-Air method)
- Cell sorter (Flow-Cell method)
- Cell Imaging Analyzer
Human Tissue Processing Division
This is a facility to process human tissue and bloods for research use. Frozen section, primary culture and purifi cation to DNA, RNA and protein , can be processed here. To avoid risks of contamination with experimental animal samples, as well as to avoid infectious accidents to human samples, materials handled in this division are limited to human samples. To further minimize the risk of cross-contamination, air pressure of each room is set to "negative."
- Safety Cabinet
- CO2 Incubator
- Refrigerated Centrifuge
Animal Model Analyses Center
Structural and functional analyses of cells and tissues sampled from animal disease model mice and rats are specialized in this center. By complementing its functionality as an animal testing center, it aims to develop and analyze model animals for disease.
- Stereoscopic microscope
- Paraffin fixation equipment for the preparation of tissue slices
- Culture equipment such as biosafety cabinets for tissue and cell cultures
- Microscopes for imaging such as a stereo microscope
- Differential interference contrast microscope
In this department, we investigate the cellular and molecular dynamics with state-of-the-art imaging techniques (e.g., two photon laser scanning microscopes, and an electron microscope). Our goal is to innovate novel diagnoses and treatments for diseases.
- Two photon laser scanning microscopes
- Electron microscope
- Confocal laser scanning microscope
- Laser microdissection
In this laboratory, integrated analyses between biology andinformatics are performed. Inaccordance with the rapid development of high throughput experiments including microarray, RNA-seq, ChIP-seq, and mass spectrometry, it is becoming increasingly necessary to take advantage of cuttingedge bioinformatics techniques dealing with massive datasets.
- TAKERU for Sequencer III
Translational Research Division
The laboratory ensures a smooth translation of first-rate outcomes in basic research for their clinical application such as disease prevention, diagnosis, and treatment. Since our university has been actively involving in cutting-edge research, and is also rich in potential themes for translational research, our laboratory supports their research for the practical application of basic research in a clinical setting for the purpose of developing new treatments and drugs. Advanced Medical Research Center provides seven research centers which allow the researchers to perform a wide range of cutting-edge joint research, and also in Biobank division, we stores and manages tissue samples (e.g. excised tissue during surgery, or serum) and clinical information provided by patients at the University Hospital, as medical resources for future use in basic research.