Gut microbes and immune system associated with arteriosclerosis

Posted on Posted in AMRC Research

Date: 20 Oct 2016   Diabetes, hypertension, dyslipidemia, chronic kidney disease, and smoking are some of the risk factors of arteriosclerosis, which may eventually lead to cardiac or cerebral infarction. Health-conscious people would exercise and eat a balanced diet, avoiding fatty food and overeating, so that they can prevent the afore-mentioned risky conditions. However, such […]

Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

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Date: 15 Nov 2016   There is currently no reliable serum biomarker for ovarian clear cell carcinoma (CCC), a highly lethal histological subtype of epithelial ovarian cancer (EOC). Previously, using a proteome-based approach, we identified tissue factor pathway inhibitor 2 (TFPI2) as a candidate serum biomarker for CCC. In this study, we sought to evaluate the […]

CiRA, Takeda and Yokohama City University enters a Joint Research Agreement on an iPS Cell Research Project

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Date: 09 Nov 2016   Launching a Research Project on Application of Miniature Liver Technology to Drug Discovery as Part of T-CiRA Kyoto, Osaka and Yokohama, Japan, November 9, 2016 –the Center for iPS Cell Research and Application, Kyoto University (CiRA), Takeda Pharmaceutical Company Limited (Takeda) and Yokohama City University announced today that they entered […]

Computer-Assisted Rotational Acetabular Osteotomy for Patients with Acetabular Dysplasia

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Date: Feb 13 2016   Rotational acetabular osteotomy (RAO) is a well-established surgical procedure for patients with acetabular dysplasia, and excellent long-term results have been reported. However, RAO is technically demanding and precise execution of this procedure requires experience with this surgery. The usefulness of computer navigation in RAO includes its ability to perform three-dimensional […]

The current status and future prospects of computer-assisted hip surgery

Posted on Posted in AMRC Research

Date: 29 Sep 2016   The advances in computer assistance technology have allowed detailed three-dimensional preoperative planning and simulation of preoperative plans. The use of a navigation system as an intraoperative assistance tool allows more accurate execution of the preoperative plan, compared to manual operation without assistance of the navigation system.   In total hip […]

Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy

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Date: 23 Sep 2016   We describe four families with affected siblings showing unique clinical features: early-onset (before 1 year of age) progressive diffuse brain atrophy with regression, postnatal microcephaly, postnatal growth retardation, muscle weakness/atrophy, and respiratory failure. By whole-exome sequencing, we identified biallelic TBCD mutations in eight affected individuals from the four families. TBCD […]

Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity

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Date: 10 Aug 2016   Interferon regulatory factor-5 (IRF5), a transcription factor critical for the induction of innate immune responses, contributes to the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE) in humans and mice. Lyn, a Src family kinase, is also implicated in human SLE, and Lyn-deficient mice develop an SLE-like disease. Here, […]

12-Gene Recurrence Score Assay Stratifies the Recurrence Risk in Stage II/III Colon Cancer With Surgery Alone: The SUNRISE Study

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Date: 25 Jun 2016   Stratification of patients into stage II and III colon cancer according to their risk of disease recurrence allows identification of those who should derive the most benefit from adjuvant chemotherapy and limits overtreatment in patients for whom the toxicities of adjuvant chemotherapy outweigh relatively low absolute benefits.   At present, […]

An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

Posted on Posted in AMRC Research

Date: 22 Jun 2016   Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis, and their genetic abnormalities cause one type of hereditary salt-sensitive hypertension, Liddle syndrome. As we reported previously, both human and rodent Nedd4L/Nedd4-2 showed molecular diversity, with and without a C2 domain in their N-terminal. Nedd4L/Nedd4-2 […]

Development of monoclonal antibody and diagnostic test for Middle East respiratory syndrome coronavirus using cell-free synthesized nucleocapsid antigen

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Date: 27 Apr 2016   Protein nativity is one of the most critical factors for the quality of antigens used as immunogens and the reactivities of the resultant antibodies. The preparation and purification of native viral antigens in conventional cell-based protein expression systems are often accompanied by technical hardships. These challenges are attributable mainly to […]