Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS

Posted on Posted in AMRC Research

Date: 21 Sep 2017

 

Axonal regeneration in the adult mammalian central nervous system is limited in part by the non-permissive environment, including axonal growth inhibitors such as the Nogo-A protein. How the functions of these inhibitors can be blocked remains unclear. Here, we examined the role of LOTUS, an endogenous Nogo receptor antagonist, in promoting functional recovery and neural repair after spinal cord injury (SCI), as well as axonal regeneration after optic nerve crush. Wild-type untreated mice show incomplete but substantial intrinsic motor recovery after SCI. The genetic deletion of LOTUS delays and decreases the extent of motor recovery, suggesting that LOTUS is required for spontaneous neural repair. The neuronal overexpression of LOTUS in transgenic mice promotes motor recovery after SCI, and recombinant viral overexpression of LOTUS enhances retinal ganglion cell axonal regeneration after optic nerve crush. Thus, the level of LOTUS function titrates axonal regeneration.

 

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Kohtaro TAKEI

E-mail: kohtaro@yokohama-cu.ac.jp   Phone: +81 45 508 7240, +81 45 508 7628

 

Professor, Department of Molecular Medical Bioscience Laboratory,
Graduate School of Medical Life Science,Yokohama City University

1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 JAPAN