Prof. Tamura (Immunology) and his colleagues identified a critical transcription factor cascade in the development of monocytes, a immune cell type important for innate immune responses, tissue homeostasis, and cancer biology.

Posted on Posted in AMRC Research

Date: 14 Jan 2013

 

“IRF8 induces the Klf4 gene in myeloid progenitors. This transcription factor cascade is essential for Ly6C+ monocyte development. IRF8 binding to genomic targets promotes H3K4me1, a chromatin signature for promoter-distal enhancers, thereby inducing gene expression.”

 

Link to abstract

 

Tomohiko Tamura
Professor, Yokohama City University, Department of Immunology, Graduate School of Medicine
Phone: +81-45-787-2612
e-mail: tamurat@yokohama-cu.ac.jp
URL: http://www-user.yokohama-cu.ac.jp/~immunol/