YOKOHAMA CITY UNIVERSITY

Amino- and carboxyl-terminal domains of ​Filamin-A interact with ​CRMP1 to mediate ​Sema3A signalling

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Sema 3A is involved in the guidance of axons during nervous system development and induces the reorganization of actin filaments in the growth cones through the downstream protein CRMP1. Here the authors study the details of the molecular interaction between CRMP1 and the actin-binding protein Filamin-A in C. elegans.

Nature Communications 5, Article number: 5325 | doi:10.1038/ncomms6325,
Published 31 October 2014

Yoshio Goshima, M.D. & Ph.D. Professor,
Fumio Nakamura , Associate Professor, Department of Molecular Pharmacology & Neurobiology,
Graduate School of Medicine,Yokohama City University
Tel: 81-45-787-2595
e-mail: f-nakamura@umin.ac.jp
goshima@med.yokohama-cu.ac.jp
URL: http://www-user.yokohama-cu.ac.jp/~pharmac/

 

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