YOKOHAMA CITY UNIVERSITY

Prof. Yoshio Goshima and his colleagues (Molecular Pharmacology and Neurobiology) discover a new causal molecule that causes Schizophrenia!

Home > Research > Prof. Yoshio Goshima and his colleagues (Molecular Pharmacology and Neurobiology) discover a new causal molecule that causes Schizophrenia!
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Assistant Prof. Naoya Yamashita and Prof. Yoshio Goshima (Department of Pharmacology and Neurobiology
Yokohama City University Graduate School of Medicine) have discovered that a molecule which is recognized as having impaired expression in schizophrenic patients is involved in the pathogeny of schizophrenia.

*This research was carried out as part of the Ministry of Education, Culture, Sports, Science and Technology’s "Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program" and was carried out based on fellowship grants by the Japan Science and Technology Agency, the Japan Society for the Promotion of Science, and the Yokohama Foundation for Advancement of Medical Science.

Points of Research Results

・It was discovered that mice that cannot express the protein "CRMP1" which fulfills an important role in the formation of the brain, show behavioral abnormality that is similar to the symptoms shown by schizophrenia patients.

・Upon administering therapeutic drugs for schizophrenia to mice that cannot express "CRMP1" their symptoms improved.

・Since it is becoming clear that "CRMP1" is no longer functioning properly in some schizophrenia patients, this knowledge is thought as being linked to the clarification of new mechanisms that cause the development of schizophrenia, as well as to the development of therapeutic drugs.


This result of research is published at "Frontiers in Behavioral Neuroscience" on December 27, 2013. (online edition).

Yoshio Goshima, M.D. & Ph.D.
Professor, Department of Molecular Pharmacology & Neurobiology, Graduate School of Medicine,
Yokohama City University
Tel: 81-45-787-2593/2594
e-mail: goshima@med.yokohama-cu.ac.jp
URL: http://www-user.yokohama-cu.ac.jp/~pharmac/

 

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